Enter the Gungeon is a shooting game where you use one stick for running around and the other to aim. These twin-stick controls combine with loads of enemy bullets to dodge to create a tough challenge. You play four adventurers descending into the dungeon to find a time machine that has the power to kill their past. Levels are generated fresh each time you play them. You die a lot but slowly acquire new guns, items and abilities.

Like The Binding of Isaac, play involves quick reactions and movement/shooting strategy. You choose one of four protagonists, each with different abilities - calling in support or lockpicking chests. You dodge bullets, flip tables for cover and shoot enemies to work through multiple floors and rooms, each with a set of enemies with varying strength, endurance, and attack behaviour.

As you progress you find and use the huge array of firearms. 300 different guns and items can be combined to achieve more powerful effects called Synergies. Then, to complete the floor you must defeat the boss who will grant you a special gun or item. You can also rescue non-player characters who then help the player upgrade between runs.

If you enjoy this game, there is a spin-off, Exit the Gungeon, which uses a platform game-approach instead of the top-down dungeon crawler.